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Functions as a for metabolic reaction required for synthesis of purines and pyrimidines: co-enzyme The reaction depends on methyl cobalamin as a co-factor and is also dependent on folate, in which the methyl group of methyltetrahydrofolate is transferred to homocysteine to form methionine and tetrahydrofolate

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however, those with G6PD deficiency may exhibit more severe side effects than those with in-tact G6PD as a result of a decreased threshold for processing ROS in the liver